NI LAB
NUS Diagnostic Radiology
NI LAB
We leverage on novel nucleic acids modification techniques and nanotechnologies to improve mRNA therapeutics (RNA vaccines, gene editing)
Recent Highlights
Development of glypican-3-specific chimeric antigen receptor-modified natural killer cells and optimization
as a therapy for hepatocellular carcinoma
​
June 26, 2024
​
Cao et al. developed two glypican-3 (GPC3)-specific CAR-NK-92 cell lines (GPC3-CAR-NK) and explored their antitumor efficacy as chimeric antigen receptor (CAR)-modified natural killer (NK) cell immunotherapy for hepatocellular carcinoma and the findings revealed that administration of GPC3-CAR-NK cells may be a potential strategy for the treatment of HCC, and regional delivery or their combination with MWA may optimize their efficacy against HCC and may have translational value.
​
Read more in Journal of Leukocyte Biology.
Application of radiogenomics in head and neck cancer: A new tool toward diagnosis and therapy
​
23 February 2024
​
Ong et al. reviewed radiogenomics as the latest technological frontier for establishing personalized treatments in the face of the pronounced heterogeneity seen in head and neck cancer. This review comprehensively summarizes the progress in developing radiogenomics approaches for addressing head and neck cancer.
Read more in iRadiology.
Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy
​
Oct 24, 2023
​
Wang et al. developed biomimetic nanovaccine with multivalent interleukin-15 self-transpresentation (biNV-IL-15) that allows spatiotemporal manipulation of therapeutic T cells, elicits broad spectrum antigen-specific T cell responses, and promotes cures in multiple syngeneic tumor models with minimal systemic side effects.
Read more in Nature Communications.
JOIN US AT NUS!
We are constantly seeking young researchers and students to join our lab!
If you are interested in joining us or have any inquiries, please contact Dr Ni at qqian.ni@nus.edu.sg.