Nucleic Acids Nanotechnologies for RNA Therapy and Gene Editing
We leverage on novel nucleic acids modification techniques and nanotechnologies to improve mRNA therapeutics (RNA vaccines, gene editing)
Ni Qianqian, PhD
Asst Professor, Department of Diagnostic Radiology Nanomedicine Translational Research Program
Yong Loo Lin School of Medicine
National University of Singapore
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Email: qqian.ni@nus.edu.sg
Recent Highlights
Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy
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Oct 24, 2023
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Wang et al. developed biomimetic nanovaccine with multivalent interleukin-15 self-transpresentation (biNV-IL-15) that allows spatiotemporal manipulation of therapeutic T cells, elicits broad spectrum antigen-specific T cell responses, and promotes cures in multiple syngeneic tumor models with minimal systemic side effects. Read more in Nature Communications.
Materials engineering strategies for cancer vaccine adjuvant development
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May 9, 2023
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Zhang et al. outlined the current state of materials engineering strategies, including those based on molecular adjuvants, polymers/lipids, inorganic nanoparticles, and bio-derived materials, for adjuvant development. They also elaborate on how these engineering strategies and the physicochemical features of the materials involved influence the effects of adjuvants. Read more in Chemical Society Reviews.
Activatable NIR-II Photothermal Lipid Nanoparticles for Improved Messenger RNA Delivery
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April 19, 2023
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Li et al. presented second near-infrared (NIR-II) lipid nanoparticles (LNPs) containing pH activatable NIR-II dye conjugated lipid (Cy-lipid) for potentiating mRNA delivery efficiency via a stimulus-responsive photothermal-promoted endosomal escape delivery (SPEED) strategy. Read more in Angewandte Chemie International Edition.