NI LAB
NUS Diagnostic Radiology
PUBLICATIONS
Publications at NUS
2026
58. Li B, Zhao M, Yang B, Yang T, Wang Y, Hu Y, Zhang M, Ge J, Tang X, Zhang Z, Cui H, Chen X, Yang YY, Peng L, Ni Q. Antioxidant Lipid Nanoparticles Enhance mRNA Stability for Regeneration Therapy and Gene Editing. Nat. Commun. 2026 (Paper Accepted)
57. Ni Q*, Tomalia D*, Wu J, Galanakou C, Peng L*. Precision chemical engineering of dendrimers for nucleic acid delivery. Nat. Rev. Chem. 2026 (Paper Accepted)
56. Cui H, Hu H, He X, Cui H, Ni Q. Dermal fibroblast-targeted trans-amplifying RNA nanotherapeutics for skin extracellular matrix regeneration. Journal of Controlled Release (Impact factor 11.5) 2026, DOI: 10.1016/j.jconrel.2026.114947.
55. Yang B, Li B, Zhu Y, Zhao M, Cheng Y, Zhao X, Deryn Teoh E, Zhang M, Tang X, Zhang X, Xue B, Yan J, Lin Z, Luo M, Yu H, Zhang L, Chen X*, Ni Q*. Rational design of rigid mRNA folding architecture to enhance intracellular processing and protein production. Nature Nanotechnology (Impact factor 34.9) 2026, DOI: 10.1038/s41565-025-02114-9
54. Zhang Z, Ong YH, Fan B, Yang B, Yang YY, Ni Q*. Chemical engineering strategies to enhance mRNA-LNP stability for therapeutics applications. Biomaterials Science (Impact factor 5.7) 2026, DOI: 10.1039/D5BM01635E
2025
53. Zhang M, Chen S, Hu H, Ong YH, Ni Q*. Advances and strategies in enhancing mRNA cancer vaccines. Advanced Materials (impact factor = 27.4). doi: 10.1002/adma.202509880
52. Ni Q*, Wu J, Galanakou C, Zhang C, Tomalia DA, Peng L, Dendrimer engineering to overcome delivery challenges of nucleic acids. Nature Reviews Bioengineering (impact factor = 37.6). 2025. doi: 10.1038/s44222-025-00347-w
51. Wu Z, Zhang M, Ni Q*. Co-delivering a cGAS agonist and antigen via LNPs potentiates cancer immunotherapy. Molecular Therapy Nucleic Acids (impact factor = 6.5). 2025 Dec 9;36(4). doi: 10.1016/j.omtn.2025.102724
50. Zhao X, Wu K, Zhang Y, Zhang H, Zhang X, Ni Q*, Wang Z, Xia Y. Targeted biomimetic fusogenic liposome enhances tumor accumulation, penetration, and therapeutic efficacy of siRNA therapeutics. Materials Today Bio (impact factor = 10.2). 2025 Oct 12:102414. doi: 10.1016/j.mtbio.2025.102414
49. Zheng N, Wang Q, Cao Z, Yu C, Zhang R, Xiang K, Wu H, Li K, Ni Q, Ma Q, Mu J. Multifunctional H2S‐activated metal‐organic framework systems for targeted colorectal cancer imaging and synergistic copper‐induced tumor regression. BMEMat (impact factor = 15.5). 2025:e70029. doi: 10.1002/bmm2.70029
48. Fu S, Zhang M, Calzadilla N, Zhao B, Zhang X, Yang B, McKenzie VA, Zheng A, Ni Q*, Zhang F*. Smart polymer prodrugs via responsive prodrug-initiated ring-opening polymerization of lactide for improved drug delivery. Nanoscale (impact factor = 5.1). 2025;17(17):10595-9
47. Cavazza A, Molina-Estévez FJ, Reyes ÁP, Ronco V, Naseem A, Malenšek Š, Pečan P, Santini A, Heredia P, Aguilar-González A, Boulaiz H, Ni Q, et al. Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group. Molecular Therapy Nucleic Acids (impact factor = 6.5). 2025, 36(1):102457. doi: 10.1016/j.omtn.2025.102457
2024
46. Zhang M, Wang Y, Li B, Yang B, Zhao M, Li B, Liu J, Hu Y, Wu Z, Ong Y, Han X, Ding L, Zhu K, Li J, Luo M, Chen S, Peng L, Zhang L*, Chen X*, Ni Q*, STING‐Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy. Adv. Mater (impact factor = 27.4). 2024, 2412654. doi: 10.1002/adma.202412654
45. Cao B, Ni Q, Chen Z, Yang S, Zhang X, Su H, Zhang Z, Zhao Q, Zhu X, Liu M. Development of GPC3-CAR-NK cells and optimization as a therapy for HCC. Journal of Leukocyte Biology (impact factor = 5.5). 2024. Jun 26:qiae144. doi: 10.1093/jleuko/qiae144
44. Li B, Zhao M, Lai W, Zhang X, Yang B, Chen X, Ni Q*. Activatable NIR-II photothermal lipid nanoparticles for improved messenger RNA delivery. Angew Chem Int Engl (impact factor = 16.82). 2023. 62(25): e202302676. doi: 10.1002/anie.202302676
43. Wang K, Zhang X, Ye H, Wang X, Fan Z, Lu Q, Li S, Zhao J, Zheng S, He Z*, Ni Q*, Chen X*, Sun J*. Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy. Nat Commun (impact factor = 17.69). 2023. 14(1): 6748. doi: 10.1038/s41467-023-42155-z
42. Ong YH, Zheng W, Khong PL, Ni Q*. Application of radiogenomics in head and neck cancer: A new tool toward diagnosis and therapy. iRadiology. 2024, 1-15. doi: 10.1002/ird3.61
2023
41. Zhang X, Yang B, Ni Q*, Chen X*. Materials engineering strategies for cancer vaccine adjuvant development. Chem Soc Rev (impact factor = 60.62). 2023. 52(9): 2886-2910. doi: 10.1039/d2cs00647b
40. Yang L, Lang Y, Wu H, Xiang K, Wang Y, Yu M, Liu Y, Yang B, He L, Lu G, Ni Q*, Chen X, Zhang L. Engineered Toll-like receptor nanoagonist binding to extracellular matrix elicits safe and robust antitumor immunity. ACS Nano (impact factor = 18.03). 2023. 17(6): 5340-5353. doi: 10.1021/acsnano.2c08429
39. Xiang K, Wu H, Liu Y, Wang S, Li X, Yang B, Zhang Y, Ma L, Lu G, He L, Ni Q*, Zhang L*. MOF-derived bimetallic nanozyme to catalyze ROS scavenging for protection of myocardial injury. Theranostics (impact factor = 11.6). 2023. 13(8):2721-2733. doi: 10.7150/thno.83543
Publications prior to NUS
38. Wang Y, Yang Y, Yang L, Lin Y, Tian Y, Ni Q, Wang S, Ju H, Guo J, Lu G. Gold nanostar@polyaniline theranostic agent with high photothermal conversion efficiency for photoacoustic imaging-guided anticancer phototherapy at a low dosage. ACS Appl Mater Interfaces. 2022, 14(25):28570-28580. doi: 10.1021/acsami.2c05679
37. Qiao H, Tang C, Schoepf UJ, Bayer RR, Tesche C, Jiang M, Yin C, Zhou C, Zhou F, Lu M, Jiang J, Lu G, Ni Q, Zhang L. One-year outcomes of CCTA alone versus machine learning-based FFRCT for coronary artery disease: a single-center, prospective study. Eur Radiol. 2022, 32(8):5179-5188. doi: 10.1007/s00330-022-08604-x
36. Jiang M, Zhang XL, Liu H, Tang CX, Li JH, Wang YN, Xu PP, Zhou CS, Zhou F, Lu MJ, Zhang JY, Ni Q*, et al. The effect of coronary calcification on diagnostic performance of machine learning-based CT-FFR: A Chinese multicenter study. Eur Radiol. 2021. 3(31):1482-1493. doi: 10.1007/s00330-020-07261-2
35. Zhang Y, Teng Z, Ni Q, Tao J, Cao X, Wen Y, Wu L, Fang C, Wan B, Zhang X, Lu G. Orderly curled silica nanosheets with a small size and macromolecular loading pores: synthesis and delivery of macromolecules to eradicate drug-resistant cancer. ACS Appl Mater Interfaces. 2020. 12(52):57810-57820. doi: 10.1021/acsami.0c19497
34. Ni Q, Sun Z, Qi L, Chen W, Yang Y, Wang L, Zhang X, Yang L, Fang Y, Xing Z, Zhou Z, Yu Y, Lu G, Zhang L. A deep learning approach to characterize 2019 Coronavirus Disease (COVID-19) pneumonia in chest CT images. Eur Radiol. 2020.30(12):6517-6527. doi: 10.1007/s00330-020-07044-9
33. Zhou Z, Deng H, Yang W, Wang Z, Lin L, Munasinghe J, Jacobson O, Liu Y, Tang L, Ni Q, Kang F, Liu Y, Niu G, Bai R, Qian C, Song J, Chen X. Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging. Nat Commun. 2020. 11(1):1-12. doi: 10.1038/s41467-020-16771-y
32. Zu Z, Jiang M, Xu P, Chen W, Ni Q, Lu G, Zhang L. Coronavirus Disease 2019 (COVID-19): A perspective from China. Radiology. 2020. 296(2):E15-E25. doi: 10.1148/radiol.2020200490
31. Xu P, Li JH, Zhou F, Jiang MD, Zhou CS, Lu MJ, Tang CX, Zhang XL, Yang L, Zhang YX, Wang YN, Ni Q*, et al. The influence of image quality on diagnostic performance of a machine learning based fractional flow reserve derived from coronary CT angiography. Eur Radiol. 2020. 30(5): 2525-2534. doi: 10.1007/s00330-019-06571-4
30. He L, Ni Q, Mu J, Fan W, Liu L, Wang Z, Li L, Tang W, Liu Y, Cheng Y, Tang L, Yang Z, Liu Y, Zou J, Yang W, Jacobson O, Zhang F, Huang P, Chen X. Solvent-assisted self-assembly of a metal-organic framework based biocatalyst for cascade reaction driven photodynamic therapy. J Am Chem Soc. 2020. 142(14):6822-6832. doi: 10.1021/jacs.0c02497
29. Wang X, Tian Y, Liao X, Tang Y, Ni Q, Sun J, Zhao Y, Zhang J, Teng Z, Lu G. Enhancing Selective Photosensitizer Accumulation and Oxygen Supply for High-efficacy Photodynamic Therapy Toward Glioma by 5-aminolevulinic Acid Loaded Nanoplatform. Biomaterials. 2020. 232:119677. doi: 10.1016/j.jcis.2020.01.020
28. Shi Z, Hu B, Schoepf UJ, Savage R, Dargis D, Pan C, Li X, Ni Q, Lu G, Zhang L. Artificial Intelligence in the Management of Intracranial Aneurysms: Current Status and Future Perspectives. AJNR Am J Neuroradiol. 2020. 41(3):373-379. doi: 10.3174/ajnr.A6468
27. Zhua H, Cao X, Cai X, Tian Y, Wang D, Qi J, Teng Z, Lu G, Ni Q, Wang S, Zhang L. Pifithrin-μ in gold nanoparticle amplifies pro-apoptotic unfolded protein response cascades to potentiate synergistic glioblastoma therapy. Biomaterials. 2020. 232:119677. doi: 10.1016/j.biomaterials.2019.119677
26. Ni Q, Zhang F, Liu Y, Wang Z, Yu G, Liang B, Niu G, Su T, Zhu G, Lu G, Zhang L, Chen X. 2020. A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer. Sci Adv. 6(12): eaaw6071. doi: 10.1126/sciadv.aaw607
25. Ren Q, Yang K, Zou R, Wan Z, Shen Z, Wu G, Zhou Z, Ni Q, Fan W, Hu J, Liu Y. Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics. Nanoscale. 2019. 11 (47), 23021-23026. doi: 10.1039/C9NR07725A
24. Zhou F, Tang C, Schoepf UJ, Tesche C, Rollins J, Liu H, Zhou C, Yan J, Lu M, Lu G, Ni Q, Zhang L. Machine learning using CT-FFR predicts proximal atherosclerotic plaque formation associated with LAD myocardial bridging. J Am Coll Cardiol Img. 2019. 12 (8), 1591-1593. doi: 10.1016/j.jcmg.2019.01.018
23. Yu G, Cen TY, He Z, Wang SP, Wang Z, Ying XW, Li S, Jacobson O, Wang S, Wang L, Lin LS, Tian R, Zhou Z, Ni Q, Li X, Chen X. Porphyrin nanocage-embedded single-molecular nanoparticles for cancer nanotheranostics. Angew Chem Int Engl. 2019. 58(26):8799-8803. doi: 10.1002/anie.201903277
22. Yu Y, Ni Q, Wang Z, Chen M, Zhang L. Multiparametric functional magnetic resonance imaging for evaluating renal allograft injury. Korean J Radiol. 2019. 20(6):894-908. doi: 10.3348/kjr.2018.0540
21. Ni Q, Pham NB, Meng WS, Zhu G, Chen X. Advances in immunotherapy of type I diabetes. Adv Drug Deliv Rev. 2019. 139:83-91. doi:10.1016/j.addr.2018.12.003
20. Zhang Y, Ni Q, Xu C, Wan B, Geng Y, Zheng G, Yang Z, Tao J, Zhao Y, Wen J, Zhang J, Wang S, Tang Y, Li Y, Zhang Q, Liu L, Teng Z, Lu G. Smart bacterial magnetic nanoparticles for tumor-targeting magnetic resonance imaging of Her2-positive breast cancers. ACS Appl Mater Interfaces. 2018. 11(4):3654-3665. doi: 10.1021/acsami.8b15838
19. Zhang F, Ni Q#, Jacobson O, Cheng S, Liao A, Wang Z, He Z, Yu G, Song J, Ma Y, Niu G, Zhang L, Zhu G, Chen X. Polymeric nanoparticles with a glutathione-sensitive heterodimeric multifunctional prodrug for in vivo drug monitoring and synergistic cancer therapy. Angew Chem Int Engl. 2018. 57(24):7066-7070. doi: 10.1002/anie.201801984
18. Yang Z, Tian W, Wang Q, Zhao Y, Zhang Y, Tian Y, Tang Y, Wang S, Liu Y, Ni Q, Lu G, Teng Z, Zhang L. Oxygen‐evolving mesoporous organosilica coated prussian blue nanoplatform for highly efficient photodynamic therapy of tumorsdial bridging. Adv Sci. 2018. 5 (5), 1700847. doi: 10.1002/advs.201700847
17. Ni Q, Zhang F, Zhang Y, Zhu G, Wang Z, Teng Z, Wang C, Yung BC, Niu G, Lu G, Zhang L, Chen X. In situ shRNA synthesis on DNA–polylactide nanoparticles to treat multidrug resistant breast cancer. Adv Mater. 2018. 30(10): 1-10. doi: 10.1002/adma.201705737
16. Dai Y, Yang Z, Cheng S, Wang Z, Zhang R, Zhu G, Wang Z, Yung BC, Tian R, Jacobson O, Xu C, Ni Q, Song J, Sun X, Niu G, Chen X. Toxic reactive oxygen species enhanced synergistic combination therapy by self-assembled metal-phenolic network nanoparticles. Adv Mater. 2018. 30(8): 1-8. doi: 10.1002/adma.201704877
15. Dai Y, Cheng S, Wang Z, Zhang R, Yang Z, Wang J, Yung BC, Wang Z, Jacobson O, Xu C, Ni Q, Yu G, Zhou Z, Chen X. Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase-encapsulated therapeutic metal phenolic nanoparticles. ACS Nano. 2018. 12(1):455-463. doi: 10.1021/acsnano.7b06852
14. Zhu G, Lynn GM, Jacobson O, Chen K, Liu Y, Zhang H, Ma Y, Zhang F, Tian R, Ni Q, Cheng S, Wang Z, Lu N, Yung BC, Wang Z, Lang L, Fu X, Jin A, Weiss ID, Vishwasrao H, Niu G, Shroff H, Klinman DM, Seder RA, Chen X. Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy. Nat Commun. 2017. 8(1):1-15. doi: 10.1038/s41467-017-02191-y
13. Chen W, Tian R, Xu C, Yung BC, Wang G, Liu Y, Ni Q, Zhang F, Zhou Z, Wang J, Niu G, Ma Y, Fu L, Chen X. Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy. Nat Commun. 2017. 8(1):11 pages. doi: 10.1038/s41467-017-01764-1
12. Zhang Y, Dang M, Tian Y, Zhu Y, Liu W, Tian W, Su Y, Ni Q, Xu C, Lu N, Tao J, Li Y, Zhao S, Zhao Y, Yang Z, Sun L, Teng Z, Lu G. Tumor acidic microenvironment targeted drug delivery based on pHLIP-modified mesoporous organosilica nanoparticles. ACS Appl Mater Interfaces. 2017. 9(36):30543-30552. doi: 10.1021/acsami.7b10840
11. Zhang F, Zhu G, Jacobson O, Liu Y, Chen K, Yu G, Ni Q, Fan J, Yang Z, Xu F, Fu X, Wang Z, Ma Y, Niu G, Zhao X, Chen X. Transformative nanomedicine of an amphiphilic camptothecin prodrug for long circulation and high tumor uptake in cancer therapy. ACS Nano. 2017. 11(9):8838-8848. doi: 10.1021/acsnano.7b03003
10. Yang Z, Ni Q#, Schoepf UJ, De Cecco CN, Lin H, Duguay TM, Zhou C, Zhao Y, Lu G, Zhang L. Small intracranial aneurysms: diagnostic accuracy of CT angiography. Radiology. 2017. 285(3):941-952. doi: 10.1148/radiol.2017162290
9. Tian W, Su Y, Tian Y, Wang S, Su X, Liu Y, Zhang Y, Tang Y, Ni Q, Liu W, Dang M, Wang C, Zhang J, Teng Z, Lu G. Periodic mesoporous organosilica coated prussian blue for MR/PA dual‐Modal imaging‐guided photothermal‐chemotherapy of triple negative breast cancer. Adv Sci. 2017. 4(3):1600356. doi: 10.1002/advs.201600356
8. Zhu G, Zhang F, Ni Q, Niu G, Chen X. Efficient nanovaccine delivery in cancer immunotherapy. ACS Nano. 2017. 11(3):2387-2392. doi: 10.1021/acsnano.7b00978
7. Dang M, Li W, Zheng Y, Su X, Ma X, Zhang Y, Ni Q, Tao J, Zhang J, Lu G, Teng Z, Wang L. Mesoporous organosilica nanoparticles with large radial pores via an assembly-reconstruction process in bi-phase. J Mater Chem B. 2017. 5(14):2625-2634. doi: 10.1039/C6TB03327J
6. Ni Q, Teng Z, Dang M, Tian Y, Zhang Y, Huang P, Su X, Lu N, Yang Z, Tian W, Wang S, Liu W, Tang Y, Lu G, Zhang L. Gold nanorod embedded large-pore mesoporous organosilica nanospheres for gene and photothermal cooperative therapy of triple negative breast cancer. Nanoscale. 2016. 9(4):1466-1474. doi: 10.1039/C6NR07598C
5. Fang X, Ni Q, Schoepf UJ, Zhou C, Chen G, Luo S, Fuller SR, De Cecco CN, Zhang L, Lu G. Image quality, radiation dose and diagnostic accuracy of 70 kVp whole brain volumetric CT perfusion imaging: a preliminary study. Eur Radiol. 2016. 26(11):4184-4193. doi: 10.1007/s00330-016-4225-6
4. Ni Q, Chen G, Schoepf UJ, Klitsie MAJ, De Cecco CN, Zhou C, Luo S, Lu G, Zhang L. Cerebral CTA with low tube voltage and low contrast material volume for detection of intracranial aneurysms. AJNR Am J Neuroradiol. 2016. 37(10):1774-1780. doi: 10.3174/ajnr.A4803
3. Su Y, Teng Z, Yao H, Wang S, Tian Y, Zhang Y, Liu W, Tian W, Zheng L, Lu N, Ni Q, Su X, Tang Y, Sun J, Liu Y, Wu J, Yang G, Lu G, Zhang L. A multifunctional PB@mSiO2–PEG/DOX nanoplatform for combined photothermal–chemotherapy of tumor. ACS Appl Mater Interfaces. 2016. 8(27):17038-17046. doi: 10.1021/acsami.6b01147
2. Ni Q, Tang C, Zhao Y, Zhou C, Chen G, Lu G, Zhang L. Single phase dual-energy CT angiography: one-stop-shop tool for evaluating aneurysmal subarachnoid hemorrhage. Sci Rep. 2016. 6(1):26704. doi: 10.1038/srep26704
1. Li X, Ni Q, Schoepf UJ, Wichmann JL, Felmly LM, Qi L, Kong X, Zhou C, Luo S, Zhang L, Lu G. 70-kVp high-pitch computed tomography pulmonary angiography with 40 mL contrast agent: initial experience. Aca Radiol. 2015. 22(12):1562-1570. doi: 10.1016/j.acra.2015.08.026